The album features guest appearances from Quavo, Juicy J, Kanye West, The Weeknd, Swae Lee, Chief Keef, Justin Bieber, Young Thug, and Toro y Moi.

Maroon 5, Scott, and Big Boi faced criticism for their decision to perform at the halftime show, due to the alleged blacklisting of Colin Kaepernick by the NFL and its franchises for protesting police brutality by kneeling during the national anthem before games. Several artists--including Jay-Z, Cardi B, and Rihanna--reportedly turned down offers to headline the show as a display of solidarity. In response to the controversy, Scott only agreed to participate if the NFL made a donation to a charity supporting social justice.

Jenner appeared in the music video for "Stop Trying to Be God", from Scott's 2018 album, Astroworld.

In 2018, his third studio album Astroworld was released to critical acclaim and produced his first Billboard Hot 100 number one single, "Sicko Mode" (featuring Drake).

In "Highest in the Room", Travis gets candid about Kylie and the fact that she didn't trust him. He raps: "I'm doing a show, I'll be back soon // That ain't what she wanna hear." Some fans believe Scott was secretly seeing a model named Roejan Kar while dating Kylie, but according to Kar: "None of these rumors are true, it's just the internet creating a false narrative. Please stop spreading lies & leave us alone because it's affecting real lives. Thank you."

"Power is Power" is the second song on the Game of Thrones soundtrack album entitled For the Throne. The title of the song is a line spoken by the character Cersei Lannister, but the song's lyrics revolve around the character Jon Snow. At the time, the song was interpreted as possibly foreshadowing Snow winning out at the conclusion of the show.

In May 2020, he collaborated for a second time with Spanish singer-songwriter Rosalía on her track "TKN", where he raps in Spanish for the first time. The track is a conceptual song centered around a gangster family formed by the two performers. The song sees Scott being murdered in a gang war between drug networks, while Rosalía becomes a widow who still dresses in black in order to express mourning.

In September 2020, Scott collaborated with McDonald's to launch "The Travis Scott", a variation on their Quarter Pounder with Cheese. The partnership marked the first celebrity-endorsed McDonald's meal since McDonald's collaborated with Michael Jordan to launch a "McJordan" burger in 1992.