In 2011, Mayweather paid for the funeral of former super lightweight world champion and former opponent Genaro Hernández, who died after a three-year battle with cancer.

On June 1, 2012, Mayweather reported to the Clark County Detention Center in Las Vegas to serve his jail term for domestic abuse. After serving two months, he was released from prison on August 3, 2012.

On August 26, 2017, Mayweather came out of retirement to fight UFC Lightweight Champion Conor McGregor. In front of a crowd of 14,623, Mayweather won via TKO in the 10th round, surpassing Rocky Marciano and setting the record for the longest active unbeaten streak in a professional career at 50-0.

Mayweather appeared on the fifth season of Dancing with the Stars. His partner was Ukrainian-American professional ballroom dancer Karina Smirnoff. On October 16, 2007, Smirnoff and Mayweather were the fourth couple to be eliminated from the competition, finishing in ninth place.

After analyzing data from Mayweather's 10 fights in the 2010s--all wins, with two knockouts--boxing statistician Dan Canobbio tweeted that of the 4,270 punches Mayweather threw in those 10 fights, he landed 1,833 (a 43% connection rate), making $499,181.67 each time he rammed his gloved knuckles into an opponent's temple, chin, or ribcage.