Even though the Comics Code Authority said they wouldn't approve the issues because Peter Parker's friend Harry Osborn was popping pills, Marvel published them anyway.

Richard Deacon (a.k.a. the Human Fly) was a small-time criminal who forced a Dr. Harlan Stillwell to imprint him with the genetic coding of a common housefly, giving him the abilities of flight, wall-crawling, superhuman strength, and acid vomit.

Hammerhead grew up dreaming of becoming a gangster. He was eventually recruited into one of the "families" of the criminal organization known as the Maggia.

The first Rose was Richard Fisk, the son of Wilson Fisk, who sought to overthrow his father after learning he was the Kingpin of Crime. He later became a Punisher-like vigilante, calling himself Blood Rose.

When Dr. Jonathan Ohnn first announced himself as The Spot, Spider-Man collapsed on the rooftop, laughing at the name. The Spot ended up winning that first confrontation but lost a second battle because he was tricked into throwing too many of his spots as weapons and not keeping enough to defend himself with.

The original Hobgoblin (Amazing Spider-Man #238) was amoral billionaire fashion designer Roderick Kingsley who had become obsessed with Norman Osborn, the original Green Goblin, after discovering the locations of his various hideouts. When Kingsley's villainous identity was finally exposed, he fled to the Caribbean to escape prosecution.

Spider-Man: Turn Off the Dark, a 2010 musical with music and lyrics by U2's Bono and The Edge, originally featured Reeve Carney as Peter Parker/Spider-Man and Patrick Page as Norman Osborn/Green Goblin.

In Marvel Comics' alternate future MC2 universe, May "Mayday" Parker (a.k.a. Spider-Girl) is the teenage daughter of Peter Parker and Mary Jane Watson.

After Jameson suffered a near-fatal heart attack, his wife sold the Daily Bugle to rival newspaper man Dexter Bennett, who changed the name to The DB (either standing for Dexter Bennett or Daily Bugle), and transformed it into a scandal sheet.

When Miguel O'Hara, a brilliant geneticist living in New York in the year 2099 A.D., attempted to recreate the abilities of the original Spider-Man in other people, he suffered an accident that caused half his DNA to be re-written with a spider's genetic code.